Author's response to reviews Title: Pretreatment with Intrathecal Amitriptyline Potentiates Anti-Hyperalgesic effects of Post-Surgical Systemic Amitriptyline following Spinal Nerve Ligation Authors:
نویسندگان
چکیده
Do not need to include p values in the abstract. page 4, line 1: Answer: done. The P values were erased. intrathecal pretreatment with amitriptyline potentiates the intra-abdominal amitriptyline effect on thermal hypersensitivity, reverses (present tense) Nav1.8 changes, and attenuates... Answer: done Conclusions: Concomitant ...line 7: hypersensitivity; it also decreased activated microglia and astrocytes, and restored dysregulated ... (DO NOT subscript the 1.3 and 1.8 – in several places it is fine but it is inconsistently presented)
منابع مشابه
Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation
BACKGROUND Amitriptyline, a tricyclic antidepressant and potent use-dependent blocker of sodium channels, has been shown to attenuate acute and chronic pain in several preclinical modes. The purpose of this study was to investigate whether intrathecal pretreatment with amitriptyline combined with post-injury intra-peritoneal amitriptyline is more effective than post-injury treatment alone on L5...
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Fenfluramine is an indirect agonist of 5-hydroxytryptamine (5-HT) receptors that acts by evoking 5-HT release and blocking 5-HT reuptake in neuronal cells. The current study compared the antinociceptive properties of fenfluramine with those of the tricyclic antidepressants amitriptyline and desipramine in rat models of acute, persistent, and neuropathic pain. In a rat model of neuropathic pain ...
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